Inflammation

[vc_row fullwidth=”true”][vc_column][vc_row_inner is_fullwidth_content=”false”][vc_column_inner][mk_fancy_title tag_name=”h1″ color=”#131415″ size=”20″ font_weight=”bolder” txt_transform=”uppercase” letter_spacing=”8″ margin_bottom=”0″ font_family=”Montserrat” font_type=”google” align=”center”]

INFLAMMATION

[/mk_fancy_title][vc_separator color=”custom” style=”double” el_width=”30″ accent_color=”rgba(84,84,84,0.5)”][mk_padding_divider size=”60″][mk_fancy_title color=”#131415″ size=”18″ font_weight=”600″ txt_transform=”uppercase” letter_spacing=”7″ margin_bottom=”25″ font_family=”Montserrat” font_type=”google”]

ABSTRACT

[/mk_fancy_title][mk_fancy_title color=”#e6936d” size=”16″ font_weight=”400″ txt_transform=”uppercase” letter_spacing=”2″ margin_bottom=”25″ font_family=”Montserrat” font_type=”google” align=”center”]

Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation
in a murine model of acute lung injury: Role for the adenosine A2A receptor

[/mk_fancy_title][mk_fancy_title color=”#131415″ size=”16″ line_height=”150″ margin_bottom=”25″ font_family=”Montserrat” font_type=”google”]Acute lung injury is an inflammatory condition for which treatment is mainly supportive because effective therapies have not been developed. Cannabidiol, a non-psychotropic cannabinoid component of marijuana (Cannabis sativa), has potent immunosuppressive and anti-inflammatory properties. Therefore, we investigated the possible anti-inflammatory effect of cannabidiol in a murine model of acute lung injury. Analysis of total inflammatory cells and differential in bronchoalveolar lavage fluid was used to characterize leukocyte migration into the lungs; myeloperoxidase activity of lung tissue and albumin concentration in the bronchoalveolar lavage fluid were analyzed by colorimetric assays; cytokine/chemokine production in the bronchoalveolar lavage fluid was also analyzed by Cytometric Bead Arrays and Enzyme-Linked Immunosorbent Assay (ELISA). A single dose of cannabidiol (20 mg/kg) administered prior to the induction of LPS (lipopolysaccharide) – induced acute lung injury decreases leukocyte (specifically neutrophil) migration into the lungs, albumin concentration in the bronchoalveolar lavage fluid, myeloperoxidase activity in the lung tissue, and production of pro-inflammatory cytokines (TNF and IL-6) and chemokines (MCP-1 and MIP-2) 1, 2, and 4 days after the induction of LPS-induced acute lung injury. Additionally, adenosine A2A receptor is involved in the anti-inflammatory effects of cannabidiol on LPS-induced acute lung injury because ZM241385 (4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol) (a highly selective antagonist of adenosine A2A receptor) abrogated all of the anti-inflammatory effects of cannabidiol previously described. Thus, we show that cannabidiol has anti-inflammatory effects in a murine model of acute lung injury and that this effect is most likely associated with an increase in the extracellular adenosine offer and signaling through adenosine A2A receptor.[/mk_fancy_title][mk_button dimension=”flat” size=”medium” letter_spacing=”7″ icon=”mk-moon-book” icon_anim=”side” url=”https://www.sciencedirect.com/science/article/pii/S0014299912000052?via%3Dihub” target=”_blank” nofollow=”true” align=”right” button_custom_width=”400″ bg_color=”#000000″ btn_hover_bg=”#e6936d” btn_hover_txt_color=”#ffffff”]READ THE STUDY[/mk_button][/vc_column_inner][/vc_row_inner][vc_row_inner is_fullwidth_content=”false”][vc_column_inner][mk_padding_divider size=”100″][mk_fancy_title color=”#131415″ size=”18″ font_weight=”600″ txt_transform=”uppercase” letter_spacing=”7″ margin_bottom=”25″ font_family=”Montserrat” font_type=”google”]

ABSTRACT

[/mk_fancy_title][mk_fancy_title color=”#e6936d” size=”16″ font_weight=”400″ txt_transform=”uppercase” letter_spacing=”2″ margin_bottom=”25″ font_family=”Montserrat” font_type=”google” align=”center”]

Cannabinoids, inflammation, and fibrosis

 

[/mk_fancy_title][mk_fancy_title color=”#131415″ size=”16″ line_height=”150″ margin_bottom=”25″ font_family=”Montserrat” font_type=”google”]Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs). As a class, the cannabinoids are generally free from the adverse effects associated with NSAIDs. Their clinical development thus provides a new approach to treatment of diseases characterized by acute and chronic inflammation and fibrosis. A concise survey of the anti-inflammatory actions of the phytocannabinoidsD9-tetrahydrocannabinol (THC), cannabidiol, cannabichromene, and cannabinol is presented. Mention is also made of the noncannabinoid plant components and pyrolysis products, followed by a discussion of 3 synthetic preparations—Cesamet (nabilone;Meda Pharmaceuticals,Somerset, NJ,USA), Marinol (dronabinol;THC; AbbVie, Inc., North Chicago, IL, USA), and Sativex (Cannabis extract; GW Pharmaceuticals, Cambridge United Kingdom)—that have anti-inflammatory effects. A fourth synthetic cannabinoid, ajulemic acid (AJA; CT-3; Resunab; Corbus Pharmaceuticals, Norwood, MA, USA), is discussed in greater detail because it represents the most recent advance in this area and is currently undergoing 3 phase 2 clinical trials by Corbus Pharmaceuticals. The endogenous cannabinoids, including the closely related lipoamino acids, are then discussed. The review concludes with a presentation of a possiblemechanism for the anti-inflammatory and antifibrotic actions of these substances. Thus, several cannabinoids may be considered candidates for development as anti-inflammatory and antifibrotic agents. Of special interest is their possible use for treatment of chronic inflammation, a major unmet medical need.[/mk_fancy_title][mk_button dimension=”flat” size=”medium” letter_spacing=”7″ icon=”mk-moon-book” icon_anim=”side” url=”https://www.ncbi.nlm.nih.gov/pubmed/27435265″ target=”_blank” nofollow=”true” align=”right” button_custom_width=”400″ bg_color=”#000000″ btn_hover_bg=”#e6936d” btn_hover_txt_color=”#ffffff”]READ THE STUDY[/mk_button][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row fullwidth=”true”][vc_column][vc_row_inner is_fullwidth_content=”false”][vc_column_inner][mk_padding_divider size=”100″][mk_fancy_title size=”18″ font_weight=”600″ txt_transform=”uppercase” letter_spacing=”7″ margin_bottom=”25″ font_family=”Montserrat” font_type=”google”]

RECOMMENDED PRODUCTS

[/mk_fancy_title][mk_products columns=”4″ image_size=”Condition Thumbnail” display=”top_rated” count=”4″ orderby=”rand” posts=”2986, 3473, 1400, 1471, 2650, 2653″][mk_padding_divider size=”25″][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row fullwidth=”true”][vc_column][mk_padding_divider size=”100″][mk_divider style=”thin_solid” thin_single_color=”#959595″ margin_top=”40″ margin_bottom=”0″][/vc_column][/vc_row]

Share on Google+

Leave a Reply